This paper uses a conceptual framework for the commercial determinants of health to map the potential commercial determinants of violence. It examines commercial practices directly linked with violence (e.g., firearms) and those that indirectly impact violence through the design and promotion of products; employment practices; and impacts on environment, poverty, and local resources. The paper aims to apply the framework to consider its utility for identifying risk and protective factors for violence, existing good practices, challenges, and opportunities for violence prevention.