To support the work of partner agencies in re-opening nightlife safely following the first COVID-19 lockdown, the Wales Violence Prevention Unit conducted rapid research to assess the evidence and emerging global best practice for re-opening nightlife whilst containing COVID-19 and preventing violence. The report includes key examples of how nightlife has re-opened across the world, how measures to reduce risks of COVID-19 may impact on risks of violence, and provides key considerations for opening up nightlife in Wales.